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POC is the abbreviation of proof of concept, which means to provide evidence for opinions. It is a set of suggested electronic models, which can be used to demonstrate the design of teams and customers, and allow to evaluate and confirm the conceptual design scheme. The evaluation of POC may cause the adjustment of specifications and design
function:
the commitment of design and the opinions recognized by all will be recorded in the design adjustment document for future reference. In this way, POC continues to develop. If you need help completing these tasks, you can find assistance resources at Queensland University
extended data:
evaluation and verification of POC
the process of evaluation and verification is to seek feedback from risk takers through POC and filing design documents. Through POC evaluation, risk takers may put forward requirements for adjusting specifications and design
sometimes, e to design defects or inappropriate places, the design team may have to go back to the drawing board. Customers may decide to stop designing or look for other teams because the design does not pay enough attention to the needs of customers and users, or because of the instability of customer needs
sometimes the change is caused by the customer organization or project decision-maker. Generally, at the end of the evaluation and verification process, the design commitment and the opinions accepted by all will be recorded in the design documents
this is often an important milestone in the life cycle of proct development. After the evaluation and verification, POC can continue to develop
spondylitis; AS It is a kind of chronic progressive inflammatory disease which mainly invades the spine and can involve sacroiliac joint and peripheral joint in varying degrees. The disease is also known as Marie str ü Mpell's disease, von
Bechterew's disease, rheumatoid spondylitis, deformed spondylitis, rheumatoid central type, etc. are now called as. As is characterized by inflammation and ossification of the lumbar, cervical, thoracic spinal joints and ligaments as well as sacroiliac joints. The hip joint is often involved, and other peripheral joints may also have inflammation. This disease is generally negative for rheumatoid factor, so it belongs to seronegative spondylosis with Reiter syndrome, psoriasis arthritis, enteropathic arthritis, etc
ankylosing spondylitis is actually a very old disease. Evidence of ankylosing spondylitis was found in the bones of ancient Egyptians thousands of years ago. Two thousand years ago, Hippocrates, a famous Greek doctor, described a disease in which patients had pain in the sacrum, spine and cervical spine
in 1893, the disease was first described in detail by Russian btchterev. In 1897 and 1898, strumpell and Marie reported the disease in detail respectively, so they named it as berteleev's disease and Ma Shi Er's disease. In the Yellow Emperor's Canon of internal medicine (Suwen · Bi Lun Pian) more than 2000 years ago, it was recorded that "those with kidney Bi are good at distension, Jiji takes the place of heel, and Jiji takes the place of head", describing the pathogenesis and symptoms of the disease. This disease has been called rheumatoid spondylitis or central rheumatoid arthritis in China since 1950s. In recent years, with the development of medicine, the understanding of this disease has been deepened. It is found that this disease is different from rheumatoid arthritis in terms of age, sex, location, pathological characteristics and various laboratory tests, There is no rheumatoid factor in the serum of patients with ankylosing spondylitis, but the positive rate of HLA-B27 is very high, which indicates that the disease is completely different from rheumatoid arthritis. So in 1963, the international anti rheumatism alliance named the disease as ankylosing spondylitis
in 1982, the first Chinese rheumatism Symposium affirmed the international unified nomenclature of ankylosing spondylitis. The diagnostic names of rheumatoid spondylitis and central rheumatoid arthritis have been discontinued. In the latest classification of rheumatism, it has been classified as seronegative spondyloarthropathy. But at present, some domestic experts believe that this name is not very accurate, because the involved tissues and organs are not limited to the spine, hip, knee, ankle, wrist, shoulder and other limb joints can be involved, and the eyes, heart, lung, kidney and other organs are often involved, which should be a systemic disease, but this diagnostic name is still commonly used at home and abroad.
to see if there is any damage to the meniscus.
incidence rate of white race is 0.05%, and incidence rate is mostly in males. The ratio of men to women is 10: 1. But recent studies have found that female cases, both in clinical manifestations and X-ray manifestations, progress slowly. Because the symptoms are not serious enough, the diagnosis is often delayed, resulting in the phenomenon of rare female cases. Female cases tend to be mild or subtype, the estimated ratio between men and women is about 7:3< According to the results of HLA-B27 screening in normal people, 20-25% of B27 positive people showed sacroiliac joint and spondylitis on X-ray. The incidence rate of this disease can be as high as 1.5% if the subclinical and mild cases are included. But there are also reports of HLA-B27 positive people, 5% have ankylosing spondylitis. The reason why the incidence of sacroiliac arthritis is different is that the diagnostic criteria of sacroiliac arthritis are different, which makes the incidence of sacroiliac arthritis significantly different. It must be pointed out that not all patients with sacroiliac arthritis and symptoms can be diagnosed as ankylosing spondylitis< The etiology of ankylosing spondylitis is still unknown, which may be related to genetic predisposing factors. It is not clear how HLA-B27 affects the pathogenesis of the disease, but it must be noted that B-27 is closely related to the pathogenesis of ankylosing spondylitis. Not all patients with B-27 antigen will develop the disease, and the existence of B27 is not enough to make everyone sick. It seems that B27 itself is not important, mainly because of the imbalance between B27 and other genes, which changes the immune response and makes the body prone to disease. It is likely that B27 antigen, as the receptor of virus or other foreign factors, plays a role in the pathogenesis of the disease; It is also possible that B27 antigen is similar to foreign factors, which makes these factors play an abnormal immune response and cause disease. There are many kinds of external factors. Infection has long been suspected as the main factor, but it has not been confirmed. At present, gram negative Enterobacteriaceae, such as pneumonia, may play a role in the pathogenesis of the disease
as for whether the pathogenic factor is B27 itself or the gene closely related to B27, it is not known that B27 gene can affect the severity of the disease, but it is not sure that it can affect the development of the disease
infection factors: recent studies have found that the occurrence of this disease may be related to infection
endocrine disorders or metabolic disorders: since rheumatoid arthritis is more common in women and ankylosing spondylitis is more common in men, it is considered that endocrine disorders are related to the disease. However, no obvious effect has been achieved in the treatment of rheumatoid arthritis with hormone, and the relationship between hormone imbalance and rheumatoid arthritis has not been confirmed. There was no significant increase or decrease in the incidence of rheumatoid or ankylosing spondylitis in patients with adrenocortical hyperfunction< Other factors: age, physique, malnutrition, climate, water and soil, humidity and cold. Others include trauma, parathyroid disease, upper respiratory tract infection and local suppurative infection, which may be related to this disease, but the evidence is insufficient.
The status of academic papers published in core journals at home and abroad, the title of the paper, the name of the journal, the state of the journal, the volume ranking, the diagnostic value and safety observation of ITT test. Effect of lentivirus mediated TCF7L2 gene RNAi on the expression of GPR40 in pancreatic btc6 cells. Guangdong Medical University, 2012, 33 (4): 449-452, changes and influencing factors of serum pregnancy associated protein a level in AGHD patients, Journal of Chongqing Medical University, 2011, 36 (6): 734-737, correlation between RBP4 gene polymorphism and type 2 diabetes mellitus by MALDI-TOF-MS, Association of rs7903146 and rs11198218 single nucleotide polymorphisms of TCF7L2 gene with early insulin secretion in newly diagnosed type 2 diabetic patients. Journal of Chinese PLA medicine 2011; 363：269-272 2. Changes of serum visfatin levels in patients with gestational diabetes mellitus. Chinese Journal of Shandong University Medical Edition, 2011, 49 (1): 19-22 2 matrix assisted laser desorption ionization time of flight mass spectrometry for detection of visfatin gene polymorphism in patients with type 2 diabetes mellitus. Guangdong Medical University, 2011, 32 (2): 188-190 2 publication of monographs and teaching materials (Note: indicate the teaching materials or monographs after the title of the book) name category publishing unit date ranking clothing, food, basic necessities of life and diabetes prevention monograph people's Military Medical Publishing House 2012-06-01 3 andrology surgery skills and complications prevention monograph people's Military Medical Publishing House 2011-07-13 5 achievement award achievement name award department level completion date certificate Second prize of science and technology progress award 1 epidemiological investigation of diabetes and related diseases in Chongqing second prize of science and technology progress award 2 basic and clinical research of insulin degradation inhibitor third prize of Ministry of science and technology progress award 3 second prize of science and technology progress award of family investigation and genetic marker research of diabetes 5 second prize of Ministry of science and Technology Progress Award Basic and clinical research on related factors of type 2 diabetes mellitus in Chinese population national third prize science and technology progress award 3 several candidate gene screening of type 2 diabetes families second prize science and technology progress award 1 Establishment of clamp operation and Research on Mechanism of insulin resistance provincial third prize science and technology progress award 6 major scientific research projects project name task source completion form completion date The main conclusions of identification and acceptance unit ranked type 2 diabetes pedigree investigation and genetic marker research international cooperation research project The Ministry of Electronic Science and technology of the people's Republic of China has written a study on serum proteomics of type 2 diabetic families. The National Natural Science Foundation of the people's Republic of China has written a study on SNPs of AMPK gene function of type 2 diabetic families. Chongqing Municipal Science and Technology Commission has written a Study on the effect of 1 gene recombinant MafA adenovirus on insulin proction in hepatocytes. Chongqing Municipal Science and Technology Commission has passed several candidate gene screening of type 2 diabetic families Site identification: Chongqing Municipal Health Bureau has passed the study on neuropeptide Y gene expression in type 12 diabetic families. Chongqing Municipal Science and Technology Commission has passed the study on the effect of 1 TCF7L2 gene polymorphism on pre insulin level in diabetic patients. Chongqing Municipal Health Bureau is accepting the effect and mechanism of 1 TCF7L2 siRNA interference on pancreatic islet cells. The First Affiliated Hospital of Chongqing Medical University is accepting the study Project name and assigned number project category project source end time scientific research funds (ten thousand yuan) I undertake the task changes and influencing factors of serum pregnancy associated protein levels in AGHD patients Research on the mechanism of TCF7L2 improving insulin resistance by regulating ide expression
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