ltc1536
1. 樓宜嘉的學術研究
中國毒理學會理事,中國葯學會應用葯理專業委員會委員,中國毒理學會生殖毒理專業委員會副主任委員,中國葯理學會葯物毒理專業委員會委員。浙江省葯學會葯理專業委員會主任委員,浙江省葯理學會副理事長,浙江省葯學會醫院葯學專業委員會委員。
《Acta Pharcologica Sinica》(SCI收錄)5,6,7屆編委,《European Journal Pharmacology》(SCI收錄)特邀注冊審稿人,《Toxicology》(SCI收錄)特邀注冊審稿人,《中國葯理學與毒理學雜志》編委,《浙江大學學報(醫學版)》編委。 幹細胞生物學與再生醫學/葯物發現;
心腦血管與肝臟葯理機制及新葯研究;
基於系統生物學的葯物毒理學研究。 2009-2011:國家自然科學基金重大研究計劃《基於誘導ES細胞定向分化的化合物庫構建和信號轉導分子事件發現》(№ 90813026,基於化學小分子探針的信號轉導過程研究專項-培育項目,合作負責人)
2007-2009:國家自然科學基金課題《ES細胞衍生肝組織系統微粒體GST表達譜及其葯物調控特徵》(№ 30672564,項目負責人);
2007-2009:浙江省「十一五」重點項目中葯現代化專項《抗老年痴呆五類中葯新葯研發》(№2006C13075,項目總負責人);
2005-2007:國家自然科學基金課題《肝膜蛋白mGST介導白三烯旁分泌/自分泌環路及其葯物調控》(№30472112,項目負責人);
2005-2006:「十五」國家科技攻關計劃重點項目《中醫葯療效及安全性基本問題研究》項目,參加「含馬兜鈴酸葯材中成葯安全性評價示範研究」機制研究內容;
2004-2006:商務部援印度尼西亞天然葯物植物研究與開發項目《護肝活性成分和抗糖尿病活性成分篩選與新葯研發》(合同號:(2004)援外成字第020號,分項目負責人);
2003-2006:國家自然科學基金中德科學基金課題《中國蔬菜中黃酮和相關多酚防治疾病活性成分研究》 [NSFC-DFG基金 №GZ051-3(147),項目負責人];
2003-2004:教育部科學技術研究重點項目《幹細胞定向分化心肌細胞葯效篩選模型應用研究》(№03088,項目負責人);
2003-2004:浙江省重點科研計劃國際合作項目《胚胎幹細胞定向分化心肌細胞模型在中葯活性成分評價中的應用研究》(№2003C24005,項目負責人);
2002-2004:國家自然科學基金課題《葯物介導胚胎幹細胞體外定向分化的干預效應研究》(№30171121,項目負責人);
2002-2004:「十五」國家攻關計劃引導項目《花粉中抑制前列腺腫瘤增生的有效成分分離及新葯開發》(任務書編號:2002BA760C,第一參加單位項目負責人);
2001-2003:國家自然科學基金課題《微粒體GST修飾激活及其對外源性物質轉化的相關性》(№30070904,項目負責人);
1999-2001:《微粒體膜GST生物學特性與腫瘤化療葯物抗性的相關性研究》(教育部留學回國人員基金,教外司留[1998]679號);
1995-1997:國家自然科學基金課題《葯源性哺乳動物著床前胚泡異常對胎仔發育影響機制研究》(№39470836,項目負責人);
1992-1994:國家自然科學基金課題《葯源性哺乳動物著床前胚泡異常對胎仔發育影響研究》(№39170875,項目負責人); 1.WO Yan-Bo, ZHU Dan-Yan, HU Ying, WANG Zhi Qiang, LIU Jian, LOU Yi-Jia*: Reactive oxygen species involved in prenylflavonoids icariin, icaritin initiated cardiomyocytes differentiation of mouse embryonic stem cells. Journal of Cellular Biochemistry 2008;103(5):1536-1550.
2.Yandong Zhang, Zhe Chen, Yijia Lou*, YongpingYu*: 2,3-Disubstituted 8-arylamino-3H-imidazo[4,5-g]quinazolines: a novel class of antitumor agents. European Journal of Medicinal Chemistry 2008;(in press, doi:10.1016/j.ejmech.2008.01.009).
3.Ming Zheng, Linhai Qu, Yijia Lou*: Effects of icariin combined with the Panax notoginseng saponins on ischemia reperfusion-inced cognitive impairments related with oxidative stress and CA1 of hippocampal neurons in rat.
Phytotherapy Research 2008;22(5):597-604.
4.Danyan Zhu, Yue Du, Xin Huang, Meiyuan Guo,kuifen Ma, Yongping Yu, Yijia Lou*:MAPEG Expression in Murine Embryonic Stem Cell-Derived Hepatic Tissue System. Stem cells and Development 2008;17(4):775-84.
5.Ling Ding, Xingguang Liang, Ying Hu, Danyan Zhu, Yijia Lou*: Involvement of p38MAPK and reactive oxygen species in icariin-inced cardiomyocyte differentiation of murine embryonic stem cells in vitro. Stem cells and Development 2008;(in press, doi:10.1089/scd.2007.0206).
6.Yanbo Wo, Danyan Zhu, Yongping Yu, Yijia Lou*: Involvement of NF-κB and AP-1 activation in icariin promoted cardiac differentiation of mouse embryonic stem cells. Eur J Pharmacol. 2008;31;586(1-3):59-66.
7.Kuifen Ma, Ziqi Ye, Zhe Chen, Luoyang Qi, Danyan Zhu, and Yijia Lou*
Enhanced expressions and activations of leukotriene C4 synthesis enzymes in D-galactosamine/ lipopolysaccharide inced rat fulminant hepatic failure model. World J Gastroenterology 2008;14(7):2748-2756.
8.Ling Ding, Xingguang Liang, Danyan Zhu, Yijia Lou* Icariin promoted expression of PGC-1α, PPARα, and NRF-1 ring cardiomyocyte differentiation of murine embryonic stem cells in vitro. Acta Pharmacologica Sinica 2007;28(10):1541-1549.
9.Ding Ling; Liang Xingguang, Zhu Danyan, Lou Yijia*: Peroxisome proliferator-activated receptor α is involved in cardiomyocyte differentiation of murine embryonic stem cells in vitro. Cell Biology International 2007; 31:1002-1009.
10.Qing-wei Zhao, Xin Huang, Yij-ia Lou*, Weber Nadine, Peter Proksch: Effects of Ethanol Extracts from Adzuki Bean (Phaseolus angularis Wight.) and Lima Bean (Phaseolus lunatus L.) on Estrogen and Progesterone Receptor Phenotypes of MCF-7 /BOS Cells. Phytotherapy Research 2007; 21:648-652.
11.Jiang Guo-Jun, Li Tie-jun, Qiu Yan, Chen Wan-Sheng, Lou Yi-Jia*: RNA interference for HIF-1α inhibits foam cells formation in vitro. Eur J Pharmacol. 2007;562(3):183-190.
12.Xin Huang, Danyan Zhu, Yijia Lou*: A Novel Anticancer Agent, Icaritin, Inced Cell Growth Inhibition, G1 Arrest and Mitochondrial Transmembrane Potential Drop in Human Prostate Carcinoma PC-3 Cells. Eur J Pharmacol. 2007;564:26-36.
13.Ling DING, Xing-guang LIANG, Yi-jia LOU*: Time-dependence of cardiomyocyte differentiation disturbed by peroxisome proliferator-activated receptor α inhibitor GW6471 in murine embryonic stem cells in vitro. Acta Pharmacologica Sinica 2007;28(5):634-42.
14.Yao-Dong WU, Yi-Jia LOU*:A Steroid Fraction of Chloroform Extract from Bee Pollen of Brassica Campestris L. Inces Cell Cycle Arrest and Apoptosis in Human Prostate Cancer PC-3 Cells. Phytotherapy Research 2007;21(11):1087-1091.
15.Shulong Yang, Li-jun Chen, Yin Kong, Dan Xu, Yijia Lou*: Sodium nitroprusside regulated the mRNA expression of LTC4 synthase in hepatic I/R injury rats via NF-kB signaling pathway. Pharmacology 2007; May,80(1):11-20.
16.Shulong Yang, Xin Huang, Hai-Fei Chen, Dan Xu, Li-Jun Chen, Yin Kong,
Yijia Lou*: Increased Leukotriene C4 Synthesis Accompanied Enhanced Leukotriene C4 Synthase Expression and Activities of Ischemia-Reperfusion Injured Liver in Rats.
Journal of Surgical Research 2007; 140(1):36-44.
17.朱丹雁*,樓宜嘉:淫羊藿苷誘導小鼠胚胎幹細胞體外定向分化為心肌細胞方法學研究 中國葯學雜志 2007;42(9):29-33.
18.W. Wätjen*, N. Weber, Y.-J. Lou, Z.-q. Wang, Y. Chovolou, A. Kampkötter, R. Kahl, P. Proksch: Prenylation enhances cytotoxicity of apigenin and liquiritigenen in rat H4IIE hepatoma and C6 glioma cells. Food and Chemical Toxicology 2007;45(1):119-24.
19.史 強,樓宜嘉*:活性氮對肝臟微粒體GST1修飾激活的研究進展. 中國葯理學與毒理學雜志 2007;21(4):297-300.
20.Yao-Dong WU, Yi-Jia LOU*: Brassinolide, a plant sterol from pollen of Brassica napus L., inces apoptosis in human prostate cancer PC-3 cells. PHARMAZIE 2007;62(5):392-5.
21.Zhiqiang Wang, Xiangnan Zhang, Luoyang Qi, Huanhuan Wang, Yijia Lou*: Neuroprotective effects of icaritin against beta amyloid-inced neurotoxicity in primary cultured rat neuronal cells via estrogen-dependent pathway. Neuroscience. 2007; 145:911-922.
22.Hao-shu Wu, Ying-yin Li, Lin-jia Weng, Chang-xin Zhou, Qiao-jun He, Yi-jia Lou*: Ethyl acetate fraction of Acrous Calamus L. extract enhance adipocyte differentiation in 3T3-L1 cells. Phytotherapy Research 2007;21(6):562-564.
23.Shulong Yang, Yijia Lou*: Sodium Nitroprusside Decreased Leukotriene C4 Generation by Inhibiting Leukotriene C4 Synthase Expression and Activity in Hepatic Ischemia-Reperfusion Injured Rats. Biochemical Pharmacology 2007;73:724–735.
24.樓宜嘉*,陳 哲:細胞組學與葯理毒理學研究新機遇 浙江大學學報(醫學版)2007;36(3):209-216.
25.朱丹雁,張翔南,杜悅,陳燕,王志強,樓宜嘉:淫羊藿素誘導小鼠胚胎幹細胞體外定向分化為神經細胞 浙江大學學報(醫學版)2007;36(3):217-223.
26.張翔南,王歡歡,王志強,吳佳瑩,朱丹雁,樓宜嘉*:淫羊藿素抗Aβ肽致大鼠原代培養神經細胞凋亡作用 浙江大學學報(醫學版)2007;36(3):224-228.
27.郭美媛,朱丹雁,杜悅,樓宜嘉*:微粒體Ⅱ相代謝酶基因在小鼠胚胎幹細胞定向分化肝細胞中的表達 浙江大學學報(醫學版)2007;36(3):229-235.
28.馬葵芬,張相宜,齊羅揚,王燕,周長新,NINA Artanti,NOVIK Nurhidayat,LINCE Yarni,樓宜嘉*:三萜類化合物對化學損傷原代培養大鼠肝細胞的保護作用 浙江大學學報(醫學版)2007;36(3):247-254.
29.齊羅揚 馬葵芬 來芳芳杜 悅 朱丹雁 樓宜嘉*:刀豆蛋白A致小鼠肝損傷的白三烯C4合成酶系基因表達及環孢素A調控作用 浙江大學學報(醫學版)2007;36(3):241-246.
30.陳 哲,葉子奇,史強,朱丹雁,樓宜嘉*:大鼠微粒體谷胱甘肽S-轉移酶1對苯丁酸氮芥體外致腫瘤細胞毒性的影響 浙江大學學報(醫學版)2007;36(3): 236-240.
31.Jie Zhang, Yijia Lou, Jos Hoogmartens, Ann Van Schepdael: Screening of drug metabolism by CE. Electrophoresis 2006;27(23):4827-35.
32.Meihua Bao, Yijia Lou*: Isorhamnetin prevent endothelial cell (EA.hy926) injuries from oxidized LDL via activation of p38MAPK.
European J Pharmacology 2006;547(1-3):22-30;
33.Qiang shi, Haifei Chen, Yijia Lou*: Further evidence that rat liver microsomal glutathione transferase 1 is not a cellular protein target for S-nitrosylantion. Chemico-Biological Interactions 2006;162:228-236.
34.Meihua Bao, Yijia Lou*: Flavonoids from Seabuckthorn protect endothelial cells (EA.hy926) from oxidized low-density lipoprotein inced injuries via regulation of LOX-1 and eNOS expression. Journal of Cardiovascular Pharmacology 2006;48(1):834-841.
35.何旭東,吳洪海,樓宜嘉*:阿伐他汀伍用大豆異黃酮對實驗性高血脂動物的調血脂作用及相關機制研究. 中國葯理學與毒理學雜志 2006;20(5):381-386.
36.沃燕波,朱丹雁,張翔南,樓宜嘉*:光電成像系統在評價胚胎幹細胞體外定向分化為心肌細胞中的應用 中國葯理學與毒理學雜志 2006;20(6):504-509.
37.肖幸豐,王志強,樓宜嘉*:淫羊藿苷伍用三七總皂苷對小鼠免疫功能的調節作用.
中草葯 2006;37(6):233-236.
38.Zhiqiang Wang, Nadine Weber, Yijia Lou*, Peter Proksch: Prenylflavonoids as Non-Steroidal Phytoestrogen and Related Structure-activity Relationships. ChemMedChem 2006;1(4):482-488.
39.Danyan Zhu, Yijia Lou*: Icariin-mediated expression of cardiac genes and molation of nitric oxide signaling pathway ring differentiation of mouse embryonic stem cells into cardiomyocytes in vitro. Acta Pharmacologica Sinica 2006;27(3):311-20.
40.Zhang J, Ha PT, Lou Y, Hoogmartens J, Van Schepdael A*: Kinetic study of cytochrome P450 3A4 activity on warfarin by capillary electrophoresis with fluorescence detection. J Chromatogr A. 2005;1082(2):235-9.
41.Jie Zhang, Pham Thi Thanh Ha, Yijia Lou, Jos Hoogmartens, Ann Van Schepdael*: Kinetic study of CYP3A4 activity on verapamil by capillary electrophoresis. Journal of Pharmaceutical and Biomedical Analysis 2005;39:612–617.
42.Qing-wei Zhao, Bo Li, Nading Weber, Yi-jia Lou*, Prter Proksch: Estrogen-like effects of ethanol extracts from several Chinese legumes on MCF-7 cell. European Food Research and Technology 2005;221(6):828-833.
43.Haiyun Ling, Yijia Lou*: Total flavones from Elsholtzia blanda rece infarct size ring acute myocardial ischemia by inhibiting myocardial apoptosis in rats.
J Ethnopharmacology 2005;101:169-175.
44.Danyan Zhu, Linhai Qu, Xiangnan Zhang, Yijia Lou*: Icariin-madiated molation of cell cycle and p53 ring cardiomyocyte differentiation in embryonic stem cells. Eur J Pharmacol. 2005; 514:99-110.
45.Haiyun Ling, Yijia Lou*, Honghai Wu, Honggang Lou: Total flavones from Elsholtzia blanda rece infarct size and improve heart function ring acute myocardial infarction by inhibiting myocardial apoptosis in canines Acta Cardiologica 2005; 60(3):295-301.
46.Haiyong Ye, Yijia Lou*: Estrogenic effects of two derivatives of icariin on human breast cancer MCF-7 cells Phytomedicine 2005;12:735-741.
47.Jie Zhang, Zhiwei Ye, Yijia Lou*: Metabolism of malphalan by rat liver microsomal glutathione S-transferase. Chemico-Biological Interactions 2005;152:101-106;
48.葉海涌,樓宜嘉*:淫羊藿苷衍生物的制備及其雌激素樣作用研究 浙江大學學報(醫學版) 2005;34(2)131-136.
49.Danyan Zhu, Yijia Lou*: Incible effects of icariin, icaritin, and desmethylicaritin on directional differentiation of embryonic stem cells into cardiomyocytes in vitro Acta Pharmacologica Sinica 2005;26(4):477-485.
50.Qiang Shi, Yijia Lou*: Microsomal glutathione Transferase 1 is not
S-nitrosylated in rat liver microsomes or in endotoxin challenged rats. Pharmacological Research 2005;51(4):303-310.
51.Jian Liu, Haiyong Ye, Yijia Lou*: Determination of rat urinary metabolites of icariin in vivo and estrogenic activities of its metabolites on MCF-7 cells. Die Pharmazie 2005;60(2):120-125.
52.Zhiqiang Wang, Yijia Lou*: Proliferation-stimulating effects of icaritin and
desmethylicaritin in MCF-7 cells Eur J Pharmacol. 2004; 504:147-153.
53.Jian Liu, Yi-jia Lou*: Determination of icariin and metabolites in rat serum by capillary zone electrophoresis: rat pharmacokinetic studies after administration of icariin. J Pharmaceutical and Biomedical Analysis 2004; 36:365-370.
54.Jie Zhang, Zhiwei Ye, Yijia Lou*: Metabolism of chlorambucil by rat liver microsomal glutathione S-transferase. Chemico-Biological Interactions 2004; 149:61-67;
55.Ling Haiyun, Lou Yijia*, Lou Honggang, Wu Honghai: Protective effect of total flavones from Elsholtzia blanda (TFEB) on myocardial ischemia inced by coronary occlusion in canines. J Ethnopharmacology 2004;94(1);101-107.
56.Qinzhu Zheng, Yijia Lou: Pathologic characteristics of immunologic injury in primary cultured rat hepatocytes and hepatoprotection of Glycyrrhizin from cytotoxicity in vitro. Acta Pharmacologica Sinica 2003;24(8):771-777.
57.Jie Zhang, Yi-Jia Lou: Relationship between activation of microsomal glutathione S-transferase and metabolism behavior of chlorambucil. Pharmacological Research 2003;48:623-630. 1.全國高等醫葯規劃教材《葯物毒理學》,人民衛生出版社,2003,第一版;2007年,第二版(「十一五」國家重點建設高等教育規劃教材)。
2.全國高等醫葯教育規劃教材《新葯臨床前評價教程》(葯理與毒理學評價過程),浙江大學出版社,2007(面向21世紀精品課程教材,應用型本科規劃教材)。
參編著作:
1.周宏灝主編:臨床醫學專業衛生部規劃教材·英文版《Pharmacology》,人民衛生出版社,2007;第一版。承擔二個章節編寫。
2.潘家祜,李學軍主編:研究生規劃教材《生化與分子葯理學》,復旦大學出版社,2008(「十一五」國家重點建設高等教育規劃教材),
承擔:第六章 微粒體葯理學;第十六章 生化與分子葯理學的關鍵技術,第三節 幹細胞研究技術。
國際與全國會議:
1. Xiangnan Zhang, Jiaying Wu, Huanhuan Wang, Gerald Rimbach, Yijia Lou 1*: Asiatic acid attenuated Ceramide inced Neurotoxicity and Caspase 3 activation in Primary cultured rat Neuronal Cells. Nutrition Genomics Organization. SEP, 2008, Potsdam,
德國.
2.Lily Ou, Yijia Lou, Yongping YU*: Design, synthesis and effects on directional differentiation of embryonic stem cells of Icaritin Derivatives. SINO-French Workshop on Bioorgannic and Medicinal Chemistry. OCT. 2007; P84. Hangzhou, China.
3.Yandong Zhang, Zhe Chen, Jieping Yan, Ziqi Ye, Yongping Yu*, Yijia Lou*:Solid-phase Synthesis and Biological Evaluation of Quinazoline Derivatives. SINO-French Workshop on Bioorgannic and Medicinal Chemistry. OCT. 2007;;P75. Hangzhou, China.
4.Zhiqiang Wang, Jiaying Wu, Minhua Xu, Yijia Lou*:Prenylflavonoids as Nonsterodal Phytoestrogens and Relataed Struture-Activity Relationship第三屆國際分子模擬與信息技術應用學術會議 MAR. 2007. Hangzhou, China.
5.YIjia Lou, Stem cell biology and drug discovery 1st Asian-Link Workshop for Marine Natural Procts and Medicinal Plants AGU. 2007. Beijing China. 20-27.
6.第三屆全國幹細胞移植在心血管疾病應用研討會,大會特邀專題報告《幹細胞生物學與葯物研究》2007年11月,杭州。
7. Yijia Lou*, Yaodong Wu: Antitumor and immunomolatory activities of polysaccharide-protein complex from bee pollen of Brassica campestris L. ONCOLOGY RESEARCH (Meeting Abstract) 2006;15(10-12):484.
8.Xin Huang, Zhiqiang Wang, Danyan Zhu, Yijia Lou*: Cytotoxic effects of icariin and isobavachin on pc-3 cell lines. The International Congress of Asian Society of Toxicology. JUN. 2006; Zhuhai, China.
9. Zhe Chen, Luoyang Qi, Danyan Zhu, Yijia Lou*: Relationship between activation of microsomal glutathione S-transferase and development of drug resistance on PC-3, K-562 and HepG2 cell lines. The International Congress of Asian Society of Toxicology. JUN. 2006; Zhuhai, China.
10. Haifei Chen, Yijia Lou*: Activation of microsomal glutathione S-transferase 1 by acetaminophen overdose is associated with protein dimmer formation in rat primarily cultured hepatocytes. The International Congress of Asian Society of Toxicology. JUN. 2006; Zhuhai, China.
11. Qiang Shi, Yijia Lou*: Activation of microsomal glutathione S-transferase 1 by acetaminophen overdose is associated with protein dimmer formation but not metabolite adction. The International Congress of Asian Society of Toxicology. JUN. 2006; Zhuhai, China.
12. N. Weber , W. Wätjen, R. Edrada ,V. Wray, Y. Lou, Z.-q. Wang and P. Proksch: Flavonoids from Vigna angularis – composition and antioxidative effects The congress of the 54th Annual Meeting of the Society for Medicinal Plant. 2006; Helsinki. Finland.
13. Ling Ding, Xinguang Liang, Danyan Zhu, Yijia Lou*: .Peroxisome proliferator-activated receptor alpha is involved in cardiomyocyte differentiation of murine embryonic stem cells in vitro. The 5th Asian-Pacific Organization for Cell Biolog Congress. OCT. 2006. Beijing, China.
14. Kui-fen Ma, Luo-yang Qi, Dan-yan Zhu, Lin-hai Qu, Yi-jia Lou*: Cysteinyl Leukotrienes Autocrine Loop Associated with Microsomal Glutatione S-transferase-Ⅱ in Rat Hepatocytes. XI『AN SATELLITE MEETING OF THE 15th WORLD CONGRESS OF PHARMACOLOGY,2006,Xi』an, China. 111-112.
15. Zhe Chen, Danyan Zhu, Yijia Lou*: Cytotoxic effects of chlorambucil on PC-3, K562, HepG2, and P388D1 cell lines affected by rat microsomal glutathione S-transferase 1. The Second Asia-Pasific Forum on Andrology, 2006. Shanghai,China.
16. Xin Huang, Zhiqiang Wang, Danyan Zhu, Yijia Lou*: Anti-carcinoma activities of icariin, icaritin and isobavachin on PC-3 cell lines. The Second Asia-Pasific Forum on Andrology, 2006. Shanghai,China.
17.羊紅玉,劉璐璐,朱丹雁,樓宜嘉*:Beagle 犬單次口服青木香或冠心蘇合膠囊馬兜鈴酸I毒代動力學研究。中國毒理學會第二屆中青年學者科技論壇。2007年10月:36
18.葉子奇,陳海飛,陳哲,朱丹雁,樓宜嘉*:過量對乙醯氨基酚致大鼠原代培養肝細胞與人肝癌細胞HepG2 mGST1修飾激活機制研究。中國毒理學會第二屆中青年學者科技論壇。2007年10月:117 1.《淫羊藿苷在誘導胚胎幹細胞體外定向分化方面的用途》
授權公告日:2004年9月1日,專利號:ZL 02 1 60367.7;
2.《淫羊藿素或去甲淫羊藿素在制備雌激素受體調節劑中的應用》
授權公告日:2005年3月30日,專利號:ZL 03 1 29242.9;
3.《雞肝散提取物總黃酮在制備抗心血管疾病葯中的應用》
授權公告日:2006年2月15日,專利號:ZL 02 1 33759.4;
4.《含辛伐他汀、泛硫乙胺和黃酮類的組合物及其用途》
專利號:ZL 02 1 33759.4;
5.《雞肝散提取物總黃酮在制備抗眼科疾病葯中的應用》
公開號:CN1757402,公開日:2006.04.12;
6.《一種水菖蒲有效部位提取物及其用途》
公開號:CN1973877, 公開日:2007年6月6日;
7.《淫羊藿總黃酮與三七總皂苷組合物的應用》(調節代謝型谷氨酸受體自身受體作用)公開號: CN101229210, 公開日:2008.07.30;
8.《8-芳胺基-3H-咪唑[4,5-g]喹唑啉類衍生物的用途》(在制備抗腫瘤葯物中應用)公開號:CN101120945,公開日:2008.02.13;
9.《 喹唑啉咪唑化合物的用途》(組合化學庫內化合物誘導胚胎幹細胞定向分化心肌細胞)公開號:CN101254191,公開日:2008.09.03;
2. 想配置個5000RMB以內的電腦幫忙看看!!!
主機配製如下(共需4400元左右)
Intel Core 2 Duo E6550(盒) 1300 元
主頻(MHz)2330MHz
匯流排頻率(MHz)1333MHz
倍頻(倍)7
外頻 333MHz
Intel Core 2 Duo E6550(盒) CPU插槽
插槽類型LGA 775
L2緩存(KB)2MB*2
華碩 P5K SE 主板晶元 900 元
集成晶元 音效卡/網卡
主晶元組Intel P35
晶元廠商 Intel
晶元組描述採用Intel P35/ICH9晶元組
音頻晶元 集成Realtek ALC 883 8聲道音效卡
網卡晶元 板載千兆網卡
CPU_種類
Core 2 Quad/Core2 Extreme/Core 2 Duo/奔騰4/賽揚D/PentiumD
CPU_描述
支持Intel Core2 Extreme/Core2 Quad/Core2 Duo/Pentium Extreme/Pentium D/Pentium 4處理器
CPU_插槽LGA 775
匯流排頻率(MHz) FSB 1333MHz
內存類型 DDRII
內存描述
支持雙通道DDR2 800/667內存 最大8G
華碩 P5K SE 擴展插槽
顯卡插槽 PCI-E 16X
PCI 插槽 2條PCI 插槽,3條PCI-E 1X
IDE 插槽 一個IDE插槽
FDD 插槽 一個FDD,接軟碟機
SATA介面 4個SATAII介面
華碩 P5K SE I/O介面
USB 介面 12個USB 介面
PS/2介面 PS/2滑鼠,PS/2鍵盤介面
其他內部插口
1個eSATA介面
外接埠 音頻介面
華碩 P5K SE 板型
主板板型 ATX板型
如果錢有多的話,可以選用華碩 P5K 主板1390 元 性能可自已查一下,差不多,我絕得用P5K SE要穩定些!
希捷 160G 7200.10 8M(串口/5年盒) 420 元
緩存(KB)8000KB
轉速/分 7200轉/分
磁頭(個)4
平均尋道時間(ms)8.5ms
內部傳輸速率(Mb/s)683
外部傳輸速率(MB/s)150
金士頓 1GB DDR2 800 410 元 (以後可再加一條)
內存類型DDR2
適用機型台式機內存
內存容量1024MB
工作頻率(MHz)800MHz
金士頓 1GB DDR2 800 技術參數
電壓(V)2.0V
七彩虹 逸彩8500GT-GD3 CF白金版 256M V12 顯卡核心 680 元
顯卡晶元GeForce 8500GT
晶元廠商 nVIDIA
晶元位寬256 bit
製造工藝0.08 微米
核心代號 G86
核心頻率580MHz
顯存頻率1500MHz
七彩虹 逸彩8500GT-GD3 CF白金版 256M V12 顯存規格
顯存類型DDRIII
顯存容量(MB)256
顯存位寬128bit
顯存描述 採用DDRIII 1.2ns顯存
顯存速度(ns)1.2ns
最高解析度2048*1536
匯流排介面PCI-E 16X
輸出/輸入介面S-video介面(TV-Out)
顯示器介面24針DVI-I介面/15針D型(VGA)介面
DirectX 10
SP單元16個
三星 金將軍 18X全兼容光雕刻錄機TS-H652M 主要性能 270 元
光碟機種類DVD刻錄機
刻錄機規格DVD±RW/DVD-RAM
DVD最大擦寫倍速12X
DVD擦寫倍速描述 DVD-RAM 12X ;DVD+RW 8X;DVD-RW 6X
DVD最大刻錄倍速18X
DVD刻錄倍速描述 DVD+R 18X;DVD-R 18X;DVD+R DL 8X;DVD-R DL 8X
DVD最大讀取倍速16X
CD-RW擦寫倍速32X
CD-R寫入倍速48X
CDROM讀取倍速48X
航嘉電源 冷靜王鑽石Vista版 主要性能 230 元
額定功率300
電源版本 INTEL ATX12V 2.2
適用范圍 支持Intel、AMD雙核心CPU
介面描述 20+4P、3個大4P、1個小4P、4個SATA、1個方6P、可拆卸式方8P
+3.3V輸出電流 18A
+5V輸出電流 12A
+12V1輸出電流 18A
+12V2輸出電流 18A
安規認證 CCC
產品特點 l、兼容INTEL2.2版規范,可以支持中、高端配置。
2、提供了有史以來最為豐富的各類介面,4個SATA,方6PIN,可拆缷式方8PIN.對稱式雙路12V設計,較之於INTEL2.2版,大大提高了單路12V的輸出能力,對於現在的VISTA高配顯卡能提供完美支持。
3、經測試表明,能穩定支持目前最?/td>
機箱是個空架,所以任選一個就行,不必太花費
羅技鍵鼠套 G1游戲鼠套套裝 180 元
羅技是鍵鼠的老大,不介紹了
顯示器自已隨便買一台吧,選三星和飛利浦的不錯。
因為最重要的配配在主機,主機配好了,才好用!
以上配製是上個月我同學剛配的配製,用了一個月感覺真的是超快和穩定,他裝了三D繪圖POR/E設計軟體還有WOW,MU,熱血江湖等網游,玩得非常流暢,所有的配製散件全是品牌,主機里的配件一分錢一分貨,這樣的配製短時間無需升級,想玩什麼都沒問題,都是相兼容性能好,建議樓主可以好好參考下!不容錯過!